2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one

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Chemical Name:2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one
CAS No.:1335201-43-8
Molecular Formula:C₂₇H₂₅NO₂
Molecular Weight:395.501
Hs Code.:

Synonyms:2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one

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Chemical Property of 2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one

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Technology Process of 2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one

There total 3 articles about 2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1335201-33-6
1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide

: 1335201-44-9
N-(4-methoxybenzyl)-2-methyl-3,3-diphenyl-N-(prop-2-yn-1-yl)acrylamide

: 1335201-43-8
2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one

Guidance literature:: With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 40 ℃; for 12h; chemoselective reaction; Irradiation; Inert atmosphere;
DOI:10.1021/ol202178t

Reference yield:

: 19481-83-5
1-bromo-2,2-diphenylcyclopropanecarboxylic acid

: 1335201-43-8
2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 40 °C / Irradiation; Inert atmosphere

With oxalyl dichloride; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol202178t

Reference yield:

: 57719-74-1
1-Bromo-2,2-diphenyl-cyclopropanecarbonyl chloride

: 1335201-43-8
2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 40 °C / Irradiation; Inert atmosphere

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ol202178t