1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide

Base Information

Chemical Name:1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide
CAS No.:1335201-33-6
Molecular Formula:C₂₇H₂₄BrNO₂
Molecular Weight:474.397
Hs Code.:

Synonyms:1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide

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Chemical Property of 1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide

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Technology Process of 1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide

There total 2 articles about 1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98729-72-7
N-[(4-methoxyphenyl)methyl]prop-2-yn-1-amine

: 57719-74-1
1-Bromo-2,2-diphenyl-cyclopropanecarbonyl chloride

: 1335201-33-6
1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol202178t

Reference yield:

: 19481-83-5
1-bromo-2,2-diphenylcyclopropanecarboxylic acid

: 1335201-33-6
1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol202178t

Reference yield: 32.0%

: 1335201-33-6
1-bromo-N-(4-methoxybenzyl)-2,2-diphenyl-N-(prop-2-yn-1-yl)cyclopropanecarboxamide

: 1335201-44-9
N-(4-methoxybenzyl)-2-methyl-3,3-diphenyl-N-(prop-2-yn-1-yl)acrylamide

: 1335201-43-8
2-(4-methoxybenzyl)-9-phenyl-2,3,9,10-tetrahydrobenzo[4,5]cyclohepta[1,2-c]pyrrol-1(4H)-one

Guidance literature:: With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 40 ℃; for 12h; chemoselective reaction; Irradiation; Inert atmosphere;
DOI:10.1021/ol202178t