N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine

Base Information

Chemical Name:N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine
CAS No.:261786-57-6
Molecular Formula:C₄₈H₆₇Cl₂NO₆
Molecular Weight:824.969
Hs Code.:

Synonyms:N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine

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Chemical Property of N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine

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Technology Process of N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine

There total 4 articles about N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₈H₆₅Cl₂NO₆

: 261786-57-6
N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine

Guidance literature:: With sodium cyanoborohydride; In tetrahydrofuran; methanol; benzene; at 20 ℃;
DOI:10.1016/S0968-0896(99)00269-2

Reference yield:

: 154023-65-1
3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone

: 261786-57-6
N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; BuLi / tetrahydrofuran; hexane / 0.25 h / 0 °C

1.2: tetrahydrofuran; hexane / 3 h / -78 - 20 °C

1.3: 44.9 percent / aqueous citric acid / tetrahydrofuran; hexane / 20 °C / pH 4

2.1: Et₃N; magnesium sulfate / benzene; tetrahydrofuran / 48 h / 20 °C

3.1: 0.149 g / sodium cyanoborohydride / benzene; tetrahydrofuran; methanol / 20 °C

With n-butyllithium; sodium cyanoborohydride; magnesium sulfate; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; hexane; benzene; 1.1: Metallation / 1.2: Peterson olefination / 1.3: Hydrolysis / 2.1: Condensation / 3.1: Reduction;
DOI:10.1016/S0968-0896(99)00269-2

Reference yield:

: 261786-56-5
3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenal

: 261786-57-6
N-(5α-cholestan-3β-yl)-3,3-bis(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-2-propenamine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; magnesium sulfate / benzene; tetrahydrofuran / 48 h / 20 °C

2: 0.149 g / sodium cyanoborohydride / benzene; tetrahydrofuran; methanol / 20 °C

With sodium cyanoborohydride; magnesium sulfate; triethylamine; In tetrahydrofuran; methanol; benzene; 1: Condensation / 2: Reduction;
DOI:10.1016/S0968-0896(99)00269-2