3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester
• CAS No.: 434293-29-5
• Molecular Formula: C₁₉H₁₇ClN₂O₂S
• Molecular Weight: 372.875
• Mol file: 434293-29-5.mol

Synonyms:3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester

Chemical Property of 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester

There total 3 articles about 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetic acid ethyl ester (536720-16-8) → 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester (434293-29-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.0833333h; Heating;

DOI:10.1002/jccs.200500136

Reference yield:

4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione (83236-50-4) → 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester (434293-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

2: 90 percent / sodium ethoxide / ethanol / 0.08 h / Heating

With sodium ethanolate; sodium acetate; In ethanol; 2: Thorpe-Ziegler cyclisation;

DOI:10.1002/jccs.200500136

Reference yield:

chloroacetic acid ethyl ester (105-39-5) + 4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione (83236-50-4) → 3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid ethyl ester (434293-29-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.333333h; Heating;

DOI:10.1002/jccs.200500136

upstream raw materials:

[4-(4-chloro-phenyl)-3-cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetic acid ethyl ester

chloroacetic acid ethyl ester

4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione

Downstream raw materials:

[4-(4-chloro-phenyl)-6-methyl-2,3-dihydro-1H-9-thia-5,7,10-triaza-cyclopenta[b]fluoren-8-yl]-hydrazine

4-(4-chloro-phenyl)-6-methyl-2,3-dihydro-1H,7H-9-thia-5,7,10-triaza-cyclopenta[b]fluoren-8-one

8-chloro-4-(4-chloro-phenyl)-6-methyl-2,3-dihydro-1H-9-thia-5,7,10-triaza-cyclopenta[b]fluorene

4-(4-chloro-phenyl)-6-methyl-2,3-dihydro-1H-7-oxa-9-thia-5,10-diaza-cyclopenta[b]fluoren-8-one

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