(4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane

Base Information

Chemical Name:(4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane
CAS No.:169871-36-7
Molecular Formula:C₂₃H₃₂O₄Si
Molecular Weight:400.59
Hs Code.:

Synonyms:(4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane

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Chemical Property of (4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane

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Technology Process of (4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane

There total 3 articles about (4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73346-73-3
(4S,5S)-diethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate

: 169871-36-7
(4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran

2: sodium hydride

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2013.09.017

Reference yield:

: 37031-29-1,6134-82-3,6135-80-4,90613-41-5,116499-08-2,37031-30-4
(+)-dimethyl-2,3-O-isopropylidene-D-tartrate

: 169871-36-7
(4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 23 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 16 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.tetlet.2018.11.033

Reference yield:

: 77-76-9
2,2-dimethoxy-propane

: 169871-36-7
(4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-hydroxymethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / methanol; cyclohexane / 7 h / 70 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 23 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

3.2: 16 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; cyclohexane; mineral oil;
DOI:10.1016/j.tetlet.2018.11.033