4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester

Base Information

Chemical Name:4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester
CAS No.:1376611-15-2
Molecular Formula:C₂₅H₃₁FN₄O₅
Molecular Weight:486.543
Hs Code.:

Synonyms:4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester

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Chemical Property of 4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester

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Technology Process of 4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester

There total 7 articles about 4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1376611-15-2
4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 10 - 20 °C

1.2: 18 h / 10 °C

2.1: sodium carbonate / water; tetrahydrofuran / 18 h / 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / industrial methylated spirits / 18 h / 30003 Torr

4.1: dimethyl sulfoxide / 16 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; 5%-palladium/activated carbon; In tetrahydrofuran; industrial methylated spirits; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1186905-28-1
(cyclopropyl)piperidin-4-yl-carbamic acid tert-butyl ester

: 1351344-88-1
4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester

: 1376611-15-2
4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

: 4-cyclopropylaminopiperidine-1-carboxylic acid benzyl ester

: 1376611-15-2
4-fluorobenzoic acid 1-{5-[4-(tert-butoxycarbonyl(cyclopropyl)amino)piperidin-1-yl][1,2,4]oxadiazol-3-yl}cyclopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / water; tetrahydrofuran / 18 h / 20 °C

2: hydrogen / 5%-palladium/activated carbon / industrial methylated spirits / 18 h / 30003 Torr

3: dimethyl sulfoxide / 16 h / 20 °C

With hydrogen; sodium carbonate; 5%-palladium/activated carbon; In tetrahydrofuran; industrial methylated spirits; water; dimethyl sulfoxide;