4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester

Base Information

Chemical Name:4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester
CAS No.:1351344-88-1
Molecular Formula:C₁₃H₈Cl₃FN₂O₃
Molecular Weight:365.576
Hs Code.:

Synonyms:4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester

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Chemical Property of 4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester

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Technology Process of 4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester

There total 3 articles about 4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351344-87-0
4-fluorobenzoic acid 1-carbamoylcyclopropyl ester

: 4124-31-6
trichloroacetic acid anhydride

: 1351344-88-1
4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester

Guidance literature:: 4-fluorobenzoic acid 1-carbamoylcyclopropyl ester; With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 ℃; for 1h;

With water; In tetrahydrofuran;

trichloroacetic acid anhydride; With hydroxylamine; In tetrahydrofuran; ethanol; water; at 60 - 90 ℃; for 4.5h;

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 1351344-88-1
4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroform; pyridine / 0.67 h / 70 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 72 h / 20 °C

3.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 °C

3.3: 4.5 h / 60 - 90 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; pyridine; chloroform;

Reference yield:

: 1351344-86-9
4-fluorobenzoic acid 1-carboxycyclopropyl ester

: 1351344-88-1
4-fluorobenzoic acid 1-(5-trichloromethyl[1,2,4]oxadiazol-3-yl)cyclopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 72 h / 20 °C

2.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 °C

2.3: 4.5 h / 60 - 90 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran;