(R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

Base Information

Chemical Name:(R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione
CAS No.:330574-43-1
Molecular Formula:C₂₃H₂₂N₂O₄S
Molecular Weight:422.505
Hs Code.:

Synonyms:(R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

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Chemical Property of (R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

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Technology Process of (R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

There total 9 articles about (R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: acetone hexane

: 352662-23-8
(R)-2-ethoxycarbonyloxy-5-[4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]phenyl]pentanamide

: 6674-22-2,83329-50-4
1,8-diazabicyclo[5.4.0]undec-7-ene

: 330574-43-1
(R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

Guidance literature:: With hydrogenchloride; In ethanol; water;

Reference yield: 94.0%

: 352662-23-8
(R)-2-ethoxycarbonyloxy-5-[4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]phenyl]pentanamide

: 6674-22-2,83329-50-4
1,8-diazabicyclo[5.4.0]undec-7-ene

: 330574-43-1
(R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

Guidance literature:: In ethanol;

Reference yield:

: 18962-05-5
4-isopropoxybenzaldehyde

: 330574-43-1
(R)-(+)-5-[3-[4-(5-methyl-2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaOMe / methanol / 2 h / 0 °C

2.1: diisobutylaluminum hydride / CH₂Cl₂; toluene / 1.5 h / 0 - 20 °C

3.1: 89 percent / MnO₂ / CH₂Cl₂ / 14 h / 20 °C

4.1: piperidine / ethanol / 3 h / Heating

5.1: H₂ / 5percent Pd/C / dioxane; ethanol / atmospheric pressure

6.1: 59 percent / TiCl₄ / CH₂Cl₂ / 0 °C

7.1: NaH / dimethylformamide / 0.25 h / 20 °C

7.2: 71 percent / dimethylformamide / 2 h / 90 - 100 °C

8.1: 412 mg / CHIRALPAK AD / hexane; ethanol; acetic acid

With piperidine; manganese(IV) oxide; CHIRALPAK AD; hydrogen; sodium methylate; titanium tetrachloride; sodium hydride; diisobutylaluminium hydride; 5percent Pd/C; In 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; 1.1: Horner-Emmons reaction;
DOI:10.1021/jm010490l