5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione

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Chemical Name:5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione
CAS No.:159017-03-5
Molecular Formula:C₂₃H₂₂N₂O₄S
Molecular Weight:422.505
Hs Code.:

Synonyms:5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione

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Chemical Property of 5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione

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Technology Process of 5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione

There total 8 articles about 5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 178611-25-1
4-(chloromethyl)-5-methyl-2-phenylthiazol

: 159017-90-0
5-[3-(4-hydroxy-phenyl)-propyl]-oxazolidine-2,4-dione

: 159017-03-5
5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione

Guidance literature:: 5-[3-(4-hydroxy-phenyl)-propyl]-oxazolidine-2,4-dione; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

4-(chloromethyl)-5-methyl-2-phenylthiazol; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 2h; Further stages.;
DOI:10.1021/jm010490l

Reference yield:

: 18962-05-5
4-isopropoxybenzaldehyde

: 159017-03-5
5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaOMe / methanol / 2 h / 0 °C

2.1: diisobutylaluminum hydride / CH₂Cl₂; toluene / 1.5 h / 0 - 20 °C

3.1: 89 percent / MnO₂ / CH₂Cl₂ / 14 h / 20 °C

4.1: piperidine / ethanol / 3 h / Heating

5.1: H₂ / 5percent Pd/C / dioxane; ethanol / atmospheric pressure

6.1: 59 percent / TiCl₄ / CH₂Cl₂ / 0 °C

7.1: NaH / dimethylformamide / 0.25 h / 20 °C

7.2: 71 percent / dimethylformamide / 2 h / 90 - 100 °C

With piperidine; manganese(IV) oxide; hydrogen; sodium methylate; titanium tetrachloride; sodium hydride; diisobutylaluminium hydride; 5percent Pd/C; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Horner-Emmons reaction;
DOI:10.1021/jm010490l

Reference yield:

: 159017-89-7
(E)-4-isopropoxycinnamaldehyde

: 159017-03-5
5-[3-[4-[(5-Methyl-2-phenyl-4-thiazolyl)methoxy]-phenyl]propyl]-2,4-oxazolidinedione

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / ethanol / 3 h / Heating

2.1: H₂ / 5percent Pd/C / dioxane; ethanol / atmospheric pressure

3.1: 59 percent / TiCl₄ / CH₂Cl₂ / 0 °C

4.1: NaH / dimethylformamide / 0.25 h / 20 °C

4.2: 71 percent / dimethylformamide / 2 h / 90 - 100 °C

With piperidine; hydrogen; titanium tetrachloride; sodium hydride; 5percent Pd/C; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010490l