(±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole

Base Information

Chemical Name:(±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole
CAS No.:1148136-30-4
Molecular Formula:C₂₁H₂₈O₃
Molecular Weight:328.452
Hs Code.:

Synonyms:(±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole

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Chemical Property of (±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole

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Technology Process of (±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole

There total 6 articles about (±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1148136-35-9
(±)-(7-isopropyl-6-methoxybenzo[d][1,3]dioxol-5-yl)(2,6,6-trimethylcyclohex-1-en-1-yl)methanol

: 1148136-30-4
(±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole

: 4-isopropyl-5-methoxy-6-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzo[d][1,3]dioxole

Guidance literature:: With bismuth(lll) trifluoromethanesulfonate; In dichloromethane; at 25 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.tetlet.2016.06.030

Reference yield:

: 1148136-34-8
1-bromo-3-isopropyl-2-methoxy-4,5-methylenedioxybenzene

: 1148136-30-4
(±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole

: 4-isopropyl-5-methoxy-6-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzo[d][1,3]dioxole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C / Inert atmosphere; Schlenk technique

1.2: 1.08 h / -78 °C / Inert atmosphere; Schlenk technique

2.1: bismuth(lll) trifluoromethanesulfonate / dichloromethane / 12 h / 25 °C / Inert atmosphere; Schlenk technique

With bismuth(lll) trifluoromethanesulfonate; n-butyllithium; In tetrahydrofuran; dichloromethane; cyclohexane; 2.1: |Nazarov Cyclization;
DOI:10.1016/j.tetlet.2016.06.030

Reference yield:

: 7228-35-5
5-methoxybenzo[d]1,3-dioxole

: 1148136-30-4
(±)-4-isopropyl-5-methoxy-7,7,10a-trimethyl-8,9,10,10a-tetrahydro-7H-fluoreno[3,4-d][1,3]dioxole

: 4-isopropyl-5-methoxy-6-((2,6,6-trimethylcyclohex-2-en-1-ylidene)methyl)benzo[d][1,3]dioxole

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0 °C / Inert atmosphere; Schlenk technique

2.1: tin(II) trifluoromethanesulfonate / dichloromethane / Inert atmosphere; Schlenk technique

3.1: palladium on activated charcoal; hydrogen / methanol / 760.05 Torr / Schlenk technique

4.1: N-Bromosuccinimide / dichloromethane / Inert atmosphere; Schlenk technique

5.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C / Inert atmosphere; Schlenk technique

5.2: 1.08 h / -78 °C / Inert atmosphere; Schlenk technique

6.1: bismuth(lll) trifluoromethanesulfonate / dichloromethane / 12 h / 25 °C / Inert atmosphere; Schlenk technique

With bismuth(lll) trifluoromethanesulfonate; N-Bromosuccinimide; tin(II) trifluoromethanesulfonate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; 6.1: |Nazarov Cyclization;
DOI:10.1016/j.tetlet.2016.06.030