(S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate

Base Information

Chemical Name:(S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate
CAS No.:1234550-87-8
Molecular Formula:C₂₂H₂₄BrNO₄
Molecular Weight:446.341
Hs Code.:

Synonyms:(S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate

Suppliers and Price of (S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate

There total 6 articles about (S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₂BrNO₄*ClH

: 106-96-7
propargyl bromide

: 1234550-87-8
(S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate

Guidance literature:: C₁₉H₂₂BrNO₄*ClH; With lithium hydroxide monohydrate; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere; Molecular sieve;

propargyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere; Molecular sieve;
DOI:10.1021/jo100788j

Reference yield:

: 1177255-35-4
(S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

: 1234550-87-8
(S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2.1: methanol; acetyl chloride / dichloromethane / 5 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Molecular sieve

3.2: 20 h / 20 °C / Inert atmosphere; Molecular sieve

With methanol; lithium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo100788j

Reference yield:

: 1150635-60-1
C₂₂H₂₅NO₇

: 1234550-87-8
(S)-methyl 3-(5-(benzyloxy)-2-bromo-4-methoxy-3-methylphenyl)-2-(prop-2-ynylamino)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; potassium carbonate / 1 h / 0 °C / Inert atmosphere

1.2: 0 °C / pH 3

2.1: 10% palladium on activated carbon; hydrogen / methanol / 10 h / 20 °C / 760.05 Torr

3.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C / Inert atmosphere

4.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

5.1: methanol; acetyl chloride / dichloromethane / 5 h / 20 °C / Inert atmosphere

6.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Molecular sieve

6.2: 20 h / 20 °C / Inert atmosphere; Molecular sieve

With methanol; N-Bromosuccinimide; lithium hydroxide monohydrate; 10% palladium on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetyl chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo100788j