(S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

Base Information

Chemical Name:(S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate
CAS No.:1177255-35-4
Molecular Formula:C₁₇H₂₄BrNO₆
Molecular Weight:418.285
Hs Code.:

Synonyms:(S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

Suppliers and Price of (S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

There total 4 articles about (S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1177255-34-3
C₁₂H₁₆BrNO₄

: 1177255-35-4
(S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2009.05.025

Reference yield: 88.0%

: 1234550-77-6
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(3-hydroxy-4-methoxy-5-methylphenyl)propanoate

: 1177255-35-4
(S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 0 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo100788j

Reference yield:

: 1150635-60-1
C₂₂H₂₅NO₇

: 1177255-35-4
(S)-methyl 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenyl)-2-(tert-butoxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol; potassium carbonate / 1 h / 0 °C / Inert atmosphere

1.2: 0 °C / pH 3

2.1: 10% palladium on activated carbon; hydrogen / methanol / 10 h / 20 °C / 760.05 Torr

3.1: N-Bromosuccinimide / acetonitrile / 1 h / 0 °C / Inert atmosphere

With methanol; N-Bromosuccinimide; 10% palladium on activated carbon; hydrogen; potassium carbonate; In methanol; acetonitrile;
DOI:10.1021/jo100788j