11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid

Base Information

Chemical Name:11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid
CAS No.:181293-30-1
Molecular Formula:C₃₇H₅₇N₃O₃
Molecular Weight:591.878
Hs Code.:

Synonyms:11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid

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Chemical Property of 11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid

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Technology Process of 11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid

There total 12 articles about 11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 181293-28-7
1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one

: 181293-30-1
11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid

Guidance literature:: With chromium(VI) oxide; sulfuric acid; In water; acetone; for 0.25h; Heating; pH=4;
DOI:10.1002/hlca.19960790511

Reference yield:

: 100-39-0
benzyl bromide

: 181293-30-1
11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / aq. Na₂CO₃ / CH₂Cl₂ / 5 h / Heating

2: 68 percent / t-BuOK / dimethylformamide / 1 h / Ambient temperature

3: 53 percent / hydrogen / 5percent Rh/C / tetrahydrofuran / 10 h / Ambient temperature

4: 71 percent / t-BuLi / diethyl ether; pentane / -24 deg C, 8 min then r.t.

5: 90 percent / pyridinium p-toluenesulfonate / ethanol / 48 h / 55 °C

6: 89 percent / 1N aq. H₂SO₄, CrO₃, conc. H₂SO₄ / acetone; H₂O / 0.25 h / Heating; pH=4

With chromium(VI) oxide; sulfuric acid; potassium tert-butylate; hydrogen; tert.-butyl lithium; pyridinium p-toluenesulfonate; sodium carbonate; Rh on carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; pentane;
DOI:10.1002/hlca.19960790511

Reference yield:

: 92608-27-0
1,5-diazabicyclo<5.4.0>undecan-6-one

: 181293-30-1
11-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-oxo-undecanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / t-BuOK / dimethylformamide / 1 h / Ambient temperature

2: 53 percent / hydrogen / 5percent Rh/C / tetrahydrofuran / 10 h / Ambient temperature

3: 71 percent / t-BuLi / diethyl ether; pentane / -24 deg C, 8 min then r.t.

4: 90 percent / pyridinium p-toluenesulfonate / ethanol / 48 h / 55 °C

5: 89 percent / 1N aq. H₂SO₄, CrO₃, conc. H₂SO₄ / acetone; H₂O / 0.25 h / Heating; pH=4

With chromium(VI) oxide; sulfuric acid; potassium tert-butylate; hydrogen; tert.-butyl lithium; pyridinium p-toluenesulfonate; Rh on carbon; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone; pentane;
DOI:10.1002/hlca.19960790511