1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one

Base Information

Chemical Name:1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one
CAS No.:181293-28-7
Molecular Formula:C₃₇H₅₉N₃O₂
Molecular Weight:577.894
Hs Code.:

Synonyms:1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one

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Chemical Property of 1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one

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Technology Process of 1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one

There total 11 articles about 1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 181293-26-5
1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-(tetrahydro-pyran-2-yloxy)-undecan-1-one

: 181293-28-7
1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 55 ℃; for 48h;
DOI:10.1002/hlca.19960790511

Reference yield:

: 100-39-0
benzyl bromide

: 181293-28-7
1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / aq. Na₂CO₃ / CH₂Cl₂ / 5 h / Heating

2: 68 percent / t-BuOK / dimethylformamide / 1 h / Ambient temperature

3: 53 percent / hydrogen / 5percent Rh/C / tetrahydrofuran / 10 h / Ambient temperature

4: 71 percent / t-BuLi / diethyl ether; pentane / -24 deg C, 8 min then r.t.

5: 90 percent / pyridinium p-toluenesulfonate / ethanol / 48 h / 55 °C

With potassium tert-butylate; hydrogen; tert.-butyl lithium; pyridinium p-toluenesulfonate; sodium carbonate; Rh on carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1002/hlca.19960790511

Reference yield:

: 92608-27-0
1,5-diazabicyclo<5.4.0>undecan-6-one

: 181293-28-7
1-{1-[3-(4-Dibenzylamino-butylamino)-propyl]-piperidin-2-yl}-11-hydroxy-undecan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / t-BuOK / dimethylformamide / 1 h / Ambient temperature

2: 53 percent / hydrogen / 5percent Rh/C / tetrahydrofuran / 10 h / Ambient temperature

3: 71 percent / t-BuLi / diethyl ether; pentane / -24 deg C, 8 min then r.t.

4: 90 percent / pyridinium p-toluenesulfonate / ethanol / 48 h / 55 °C

With potassium tert-butylate; hydrogen; tert.-butyl lithium; pyridinium p-toluenesulfonate; Rh on carbon; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; pentane;
DOI:10.1002/hlca.19960790511