(2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran

Base Information

Chemical Name:(2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran
CAS No.:915201-17-1
Molecular Formula:C₂₉H₃₅ClO₆SSi
Molecular Weight:575.198
Hs Code.:

Synonyms:(2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran

Suppliers and Price of (2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran

There total 5 articles about (2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 86030-94-6
methyl 3-O-(tert-butyldiphenylsilyl)-2,4-dideoxy-β-D-erythro-hexopyranoside

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 915201-17-1
(2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran

Guidance literature:: In pyridine; at 20 ℃;
DOI:10.1002/chir.20782

Reference yield:

: 915201-16-0
(3R,5S)-3-tert-butyldiphenylsilyloxy-5,6-(isopropylidenedioxy)hexanal

: 915201-17-1
(2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1.1: pTsOH*Py / methanol / 1 h / Heating

1.2: 63.7 percent / pTsOH / methanol / 20 °C

2.1: pyridine / 0 - 20 °C

With pyridine; In methanol;
DOI:10.1002/ejoc.200600849

Reference yield:

: 915201-15-9
ethyl (3R,5S)-3-tert-butyldiphenylsilyloxy-5,6-(isopropylidenedioxy)hexanoate

: 915201-17-1
(2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran

Guidance literature:: Multi-step reaction with 3 steps

1.1: DIBALH / diethyl ether; toluene / 0.25 h / -78 °C

1.2: 77.2 percent / diethyl ether; toluene; methanol / -78 - 20 °C

2.1: pTsOH*Py / methanol / 1 h / Heating

2.2: 63.7 percent / pTsOH / methanol / 20 °C

3.1: pyridine / 0 - 20 °C

With pyridine; diisobutylaluminium hydride; In methanol; diethyl ether; toluene;
DOI:10.1002/ejoc.200600849