1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate

Base Information

Chemical Name:1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate
CAS No.:1402719-25-8
Molecular Formula:C₄₁H₄₅N₃O₈
Molecular Weight:707.824
Hs Code.:

Synonyms:1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate

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Chemical Property of 1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate

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Technology Process of 1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate

There total 4 articles about 1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1402719-24-7
1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1402719-25-8
1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/chem.201103833

Reference yield:

: 73685-71-9
1-(o-nitrophenyl)-2-aminoethanol

: 1402719-25-8
1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

3.1: dichloromethane; acetonitrile / 0.17 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201103833

Reference yield:

: 35947-93-4
2-azido-1-(2-nitrophenyl)ethan-1-one

: 1402719-25-8
1-(2-nitrophenyl)-2(4-pentynamido)ethyl 6-[bis(4-methoxyphenyl)-(phenyl)methoxy]hexylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

2.1: triphenylphosphine / 0 - 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 3 h / 20 °C

4.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

5.1: dichloromethane; acetonitrile / 0.17 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201103833