1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate

Base Information

Chemical Name:1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate
CAS No.:1402719-24-7
Molecular Formula:C₂₀H₂₇N₃O₆
Molecular Weight:405.451
Hs Code.:

Synonyms:1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate

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Chemical Property of 1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate

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Technology Process of 1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate

There total 5 articles about 1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35947-93-4
2-azido-1-(2-nitrophenyl)ethan-1-one

: 1402719-24-7
1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

2.1: triphenylphosphine / 0 - 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 3 h / 20 °C

4.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

5.1: dichloromethane; acetonitrile / 0.17 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201103833

Reference yield:

: 6851-99-6
2-bromo-1-(2-nitrophenyl)ethanone

: 1402719-24-7
1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide / acetone / 0 - 20 °C

2.1: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

3.1: triphenylphosphine / 0 - 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 3 h / 20 °C

5.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

6.1: dichloromethane; acetonitrile / 0.17 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; sodium azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/chem.201103833

Reference yield:

: 577-59-3
2-acetylnitrobenzene

: 1402719-24-7
1-(2-nitrophenyl)-2-(4-pentynamido)ethyl 6-hydroxyhexylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(I) bromide / chloroform; ethyl acetate / 80 °C

2.1: sodium azide / acetone / 0 - 20 °C

3.1: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

4.1: triphenylphosphine / 0 - 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

5.2: 3 h / 20 °C

6.1: dmap / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

7.1: dichloromethane; acetonitrile / 0.17 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; sodium azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; copper(I) bromide; In 1,4-dioxane; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/chem.201103833