(2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ⁴-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester

Base Information

• Chemical Name: (2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ⁴-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester
• CAS No.: 122697-95-4
• Molecular Formula: C₁₉H₂₅NO₆
• Molecular Weight: 363.411

Synonyms:(2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ⁴-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester

Chemical Property of (2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ⁴-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester

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Technology Process of (2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ⁴-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester

There total 1 articles about (2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ⁴-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + (R)-2-(tert-Butyl)-5-methyl-Δ4-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester (122697-74-9) → (2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ4-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester (122697-95-4) + (2R,2'R)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ4-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 2 h; 2.) THF, -100 deg C;

Reference yield: 96.0%

(2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ4-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester (122697-95-4) → (2R,2'R,4S,5S)-2-(tert-Butyl)-5-(2'-cyclohexyl-2'-hydroxyethyl)-1,3-oxazolidin-3,4-dicarbonsaeure-dimethylester (122697-82-9)

Guidance literature:

With hydrogen; Rh/Al₂O₃; In ethyl acetate; for 16h; under 38000 Torr;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (2R,2'S)-2-(tert-Butyl)-5-(2'-hydroxy-2'-phenylethyl)-Δ4-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester (122697-95-4) → methyl (R)-3-hydroxy-3-phenylpropanoate (58692-70-9)

Guidance literature:

Yield given. Multistep reaction;

upstream raw materials:

benzaldehyde

(R)-2-(tert-Butyl)-5-methyl-Δ⁴-1,3-oxazolin-3,4-dicarbonsaeure-dimethylester

Downstream raw materials:

methyl (R)-3-hydroxy-3-phenylpropanoate

(2R,2'R,4S,5S)-2-(tert-Butyl)-5-(2'-cyclohexyl-2'-hydroxyethyl)-1,3-oxazolidin-3,4-dicarbonsaeure-dimethylester

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