METHYL (R)-3-HYDROXY-3-PHENYLPROPANOATE

Base Information

• Chemical Name: METHYL (R)-3-HYDROXY-3-PHENYLPROPANOATE
• CAS No.: 58692-70-9
• Molecular Formula: C10H12 O3
• Molecular Weight: 180.203
• Hs Code.: 29181998
• Mol file: 58692-70-9.mol

Synonyms:Benzenepropanoicacid, b-hydroxy-, methyl ester, (R)-;(R)-Methyl 3-hydroxy-3-phenylpropanoate; Methyl (3R)-3-hydroxy-3-phenylpropionate;Methyl (R)-(+)-3-phenyl-3-hydroxypropionate; Methyl(R)-3-hydroxy-3-phenylpropionate

Chemical Property of METHYL (R)-3-HYDROXY-3-PHENYLPROPANOATE

Chemical Property:

• Vapor Pressure: 0.000484mmHg at 25°C
• Refractive Index: 1.518-1.52
• Boiling Point: 300.9°Cat760mmHg
• Flash Point: 128.4°C
• PSA: 46.53000
• Density: 1.147g/cm³
• LogP: 1.28310

Purity/Quality:

METHYL-(R)-3-HYDROXY-3-PHENYLPROPANOATE 99.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL (R)-3-HYDROXY-3-PHENYLPROPANOATE

There total 53 articles about METHYL (R)-3-HYDROXY-3-PHENYLPROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-oxo-3-phenylpropionate (614-27-7) → methyl (R)-3-hydroxy-3-phenylpropanoate (58692-70-9)

Guidance literature:

With C₃₂H₄₀F₆O₆P₂Pd; hydrogen; In acetone; at 0 ℃; for 12h; under 23272.3 Torr; enantioselective reaction; Autoclave;

DOI:10.1002/cjoc.201700645

Reference yield: 96.0%

sodium methylate (124-41-4) + 1-((R)-3-Hydroxy-3-phenyl-propionyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea (124573-27-9,124601-78-1) → methyl (R)-3-hydroxy-3-phenylpropanoate (58692-70-9) + N,N-di-((S)-1-phenylethyl)urea (19035-04-2,70954-01-7,86918-15-2)

Guidance literature:

In methanol; at 0 ℃; for 0.5h;

DOI:10.1246/cl.1999.787

Reference yield: 90.0%

methyl (2R,3S)-2-bromo-3-hydroxy-3-phenylpropanoate (274684-20-7) → methyl (R)-3-hydroxy-3-phenylpropanoate (58692-70-9)

Guidance literature:

With aluminium amalgam; at 0 ℃;

DOI:10.1039/b000335m

upstream raw materials:

diazomethane

(R)-3-phenyl-3-hydroxypropionic acid

3-hydroxy-3-phenylpropanoic acid

ethyl (R)-3-hydroxy-3-phenylpropanoate

Downstream raw materials:

(R)-3-hydroxy-3-phenyl-propionic acid hydrazide

(R)-3-phenyl-1,3-dihydroxypropane

(R)-5-hydroxy-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

C₉H₁₁⁽²⁾HO