methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate

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Chemical Name:methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate
CAS No.:1227612-53-4
Molecular Formula:C₃₆H₅₀ClIO₆
Molecular Weight:741.147
Hs Code.:

Synonyms:methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate

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Chemical Property of methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate

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Technology Process of methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate

There total 4 articles about methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951694-73-8
methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

: 1227612-53-4
methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran / Reflux

2: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux

3: (Dichloroiodo)benzene; tert-butyl alcohol / dichloromethane / 1 h / 0 °C / Photolysis; Inert atmosphere

With calcium hydride; (Dichloroiodo)benzene; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; tert-butyl alcohol; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ml200256d

Reference yield:

: obeticholic acid

: 1227612-53-4
methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / 2 h / Sonication

2: sodium hydrogencarbonate / tetrahydrofuran / Reflux

3: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux

4: (Dichloroiodo)benzene; tert-butyl alcohol / dichloromethane / 1 h / 0 °C / Photolysis; Inert atmosphere

With calcium hydride; (Dichloroiodo)benzene; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; tert-butyl alcohol; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ml200256d

Reference yield:

: 618-51-9
3-Iodobenzoic acid

: 1227612-53-4
methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux

3: (Dichloroiodo)benzene; tert-butyl alcohol / dichloromethane / 1 h / 0 °C / Photolysis; Inert atmosphere

With calcium hydride; oxalyl dichloride; (Dichloroiodo)benzene; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-formamide; tert-butyl alcohol; In dichloromethane; toluene;
DOI:10.1021/ml200256d