Technology Process of methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
There total 1 articles about methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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![methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate](/Databaselist/images/loading.webp)
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951694-73-8
methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
- Guidance literature:
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Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 20 - 30 °C / 1MPa-2MPa
2: hydrogenchloride / methanol / Reflux
3: sodium tetrahydroborate / methanol
With
hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen;
In
methanol;
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951694-73-8
methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
- Guidance literature:
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Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / tetrahydrofuran / Reflux
2: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux
With
calcium hydride; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate;
In
tetrahydrofuran; toluene;
DOI:10.1021/ml200256d
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951694-73-8
methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / tetrahydrofuran / Reflux
2: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux
3: (Dichloroiodo)benzene; tert-butyl alcohol / dichloromethane / 1 h / 0 °C / Photolysis; Inert atmosphere
With
calcium hydride; (Dichloroiodo)benzene; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; tert-butyl alcohol;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ml200256d
