methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Base Information

Chemical Name:methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
CAS No.:951694-73-8
Molecular Formula:C₂₇H₄₆O₄
Molecular Weight:434.66
Hs Code.:

methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Synonyms:methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Suppliers and Price of methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Chemical Property:

Purity/Quality:: 95-161%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Obeticholic Acid Methyl Ester is a bile acid derivative useful in research.

Technology Process of methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

There total 1 articles about methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863239-59-2,1516887-31-2
3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester

: 951694-73-8
methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 - 30 °C / 1MPa-2MPa

2: hydrogenchloride / methanol / Reflux

3: sodium tetrahydroborate / methanol

With hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; In methanol;

Reference yield:

: 951694-73-8
methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

: 1227612-52-3
methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran / Reflux

2: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux

With calcium hydride; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; In tetrahydrofuran; toluene;
DOI:10.1021/ml200256d

Reference yield:

: 951694-73-8
methyl (4R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

: 1227612-53-4
methyl 3α-acetoxy-6α-ethyl-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran / Reflux

2: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux

3: (Dichloroiodo)benzene; tert-butyl alcohol / dichloromethane / 1 h / 0 °C / Photolysis; Inert atmosphere

With calcium hydride; (Dichloroiodo)benzene; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; tert-butyl alcohol; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ml200256d