ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

Base Information

Chemical Name:ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate
CAS No.:1361940-83-1
Molecular Formula:C₃₇H₄₃N₅O₅
Molecular Weight:637.779
Hs Code.:

Synonyms:ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

Suppliers and Price of ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

There total 9 articles about ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 1361940-83-1
ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; tetrahydrofuran / 1 h / -92 °C

1.2: 0.17 h / -80 °C

2.1: N,N-dimethyl-formamide / dichloromethane / 8 h / 20 °C

2.2: 0.5 h

3.1: dibenzoyl peroxide; N-Bromosuccinimide / benzene / 4 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 100 °C / Sealed tube

With N-Bromosuccinimide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; benzene;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1361940-83-1
ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 20.5 h / 85 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 13 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 0.25 h / Inert atmosphere

3.2: 38 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 100 °C / Sealed tube

With hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 3.1: Suzuki Coupling;

Reference yield:

: 910235-64-2
2-(2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1361940-83-1
ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 13 h / 20 °C

2.1: sodium carbonate / 1,4-dioxane; water / 0.25 h / Inert atmosphere

2.2: 38 h / 100 °C

3.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 100 °C / Sealed tube

With hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; water; 2.1: Suzuki Coupling;