4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide
CAS No.:1361969-91-6
Molecular Formula:C₂₂H₃₃NO₃S
Molecular Weight:391.575
Hs Code.:

Synonyms:4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

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Chemical Property of 4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

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Technology Process of 4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

There total 7 articles about 4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1361969-81-4
4-methyl-N-((S)-2-methyl-6-(trimethylsilyl)hex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

: 1361969-91-6
4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; sealed tube; Inert atmosphere;
DOI:10.1021/ja2116298

Reference yield:

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 1361969-91-6
4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); palladium diacetate; triethylamine / dichloromethane / 20 °C / sealed tube; Inert atmosphere

4.1: potassium carbonate / methanol / 20 °C / sealed tube; Inert atmosphere

With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); n-butyllithium; palladium diacetate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ja2116298

Reference yield:

: 110-53-2
1-Bromopentane

: 1361969-91-6
4-methyl-N-((S)-2-methylhex-5-yn-3-yl)-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3.1: trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); palladium diacetate; triethylamine / dichloromethane / 20 °C / sealed tube; Inert atmosphere

4.1: potassium carbonate / methanol / 20 °C / sealed tube; Inert atmosphere

With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); potassium tert-butylate; palladium diacetate; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja2116298