(2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine

Base Information

Chemical Name:(2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine
CAS No.:172511-99-8
Molecular Formula:C₁₈H₃₀NO₄P
Molecular Weight:355.414
Hs Code.:

Synonyms:(2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine

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Chemical Property of (2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine

Chemical Property:

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Technology Process of (2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine

There total 5 articles about (2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114358-14-4
O₁-benzyl O₂-methyl (2S,4R)-4-[tert-butyl(dimethyl)silyl]oxypyrrolidine-1,2-dicarboxylate

: 172511-99-8
(2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / NaBH₄ / tetrahydrofuran; methanol / 1 h / 55 °C

2: 75 percent / I₂, Ph₃P, imidazole / benzene / 1 h / Ambient temperature

3: 64 percent / 24 h / Heating

4: H₂, p-TsOH / 10percent Pd/C / methanol / 3 h / Ambient temperature

5: Et₃N / CH₂Cl₂ / 12 h / Heating

With 1H-imidazole; sodium tetrahydroborate; hydrogen; iodine; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1016/0957-4166(95)00302-6

Reference yield:

: 104795-11-1
(2S,4R)-1-benzyloxycarbonyl-4-<(tert-butyldimethylsilyl)oxy>-2-(hydroxymethyl)pyrrolidine

: 172511-99-8
(2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / I₂, Ph₃P, imidazole / benzene / 1 h / Ambient temperature

2: 64 percent / 24 h / Heating

3: H₂, p-TsOH / 10percent Pd/C / methanol / 3 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 12 h / Heating

With 1H-imidazole; hydrogen; iodine; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane; benzene;
DOI:10.1016/0957-4166(95)00302-6

Reference yield:

: 104795-33-7
(2S,4R)-1-benzyloxycarbonyl-4-<(tert-butyldimethylsilyl)oxy>-2-(iodomethyl)pyrrolidine

: 172511-99-8
(2S,4R)-1-benzyl-2-<(diisopropylphosphonyl)methyl>-4-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / 24 h / Heating

2: H₂, p-TsOH / 10percent Pd/C / methanol / 3 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 12 h / Heating

With hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/0957-4166(95)00302-6