(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester
CAS No.:97280-29-0
Molecular Formula:C₃₂H₃₄FN₅O₆
Molecular Weight:603.65
Hs Code.:

Synonyms:(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

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Technology Process of (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

There total 3 articles about (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 97280-22-3
diethyl N-<4-<(3-fluorobenzoyl)amino>benzoyl>-L-glutamate

: 97280-29-0
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: With calcium carbonate; In N,N-dimethyl acetamide; at 25 ℃; for 115h;
DOI:10.1021/jm00148a016

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 97280-29-0
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / K₂CO₃ / ethanol / 4.75 h / Heating

2: 46 percent / CaCO₃ / N,N-dimethyl-acetamide / 115 h / 25 °C

With potassium carbonate; calcium carbonate; In ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00148a016

Reference yield:

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 97280-29-0
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / K₂CO₃ / ethanol / 4.75 h / Heating

2: 46 percent / CaCO₃ / N,N-dimethyl-acetamide / 115 h / 25 °C

With potassium carbonate; calcium carbonate; In ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00148a016