(+)-(E)-3-[(E)-1-phenyl-2-(S^S)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate

Base Information

• Chemical Name: (+)-(E)-3-[(E)-1-phenyl-2-(S^S)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate
• CAS No.: 445282-38-2
• Molecular Formula: C₂₄H₂₈O₄S
• Molecular Weight: 412.55
• Mol file: 445282-38-2.mol

Synonyms:(+)-(E)-3-[(E)-1-phenyl-2-(S^S)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate

Chemical Property of (+)-(E)-3-[(E)-1-phenyl-2-(S^S)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(E)-3-[(E)-1-phenyl-2-(S^S)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate

There total 1 articles about (+)-(E)-3-[(E)-1-phenyl-2-(S^S)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(+)-(E)-1-phenyl-2-(SS)-(p-tolylsulfinyl)hept-2-en-1-(R)-ol (445282-37-1) + propynoic acid methyl ester (922-67-8) → (+)-(E)-3-[(E)-1-phenyl-2-(SS)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate (445282-38-2)

Guidance literature:

With triethylamine; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/ol0261130

Reference yield: 58.0%

(+)-(E)-3-[(E)-1-phenyl-2-(SS)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate (445282-38-2) → 3-(R)-n-butyl-5-phenyl-4-pentynal + (+)-4-(Z)-3-(S)-n-butyl-5-phenyl-4-(RS)-(p-tolylsulfinyl)pent-4-enal + (-)-4-(Z)-3-(S)-n-butyl-5-phenyl-4-(SS)-(p-tolylsulfinyl)pent-4-enal + (+/-)-4-(E)-3-(S)-n-butyl-5-phenyl-4-(RS)-(p-tolylsulfinyl)pent-4-enal

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; In N,N-dimethyl-formamide; at 134 ℃; for 3h;

DOI:10.1021/ol0261130

Reference yield: 57.0%

(+)-(E)-3-[(E)-1-phenyl-2-(SS)-(p-tolylsulfinyl)hept-2-en-1-(R)-oxy]methyl acrylate (445282-38-2) → C15H18O (1132095-74-9) + (-)-(3S,SS)-4-(Z)-3-n-butyl-5-phenyl-4-(p-tolylsulfinyl)pent-4-enal (1132096-26-4) + (+)-(3R,SS)-4-(E)-3-n-butyl-5-phenyl-4-(p-tolylsulfinyl)pent-4-enal

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; In N,N-dimethyl-formamide; at 134 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.200801680

upstream raw materials:

(+)-(E)-1-phenyl-2-(S^S)-(p-tolylsulfinyl)hept-2-en-1-(R)-ol

propynoic acid methyl ester

Downstream raw materials:

(-)-(3S,SS)-4-(Z)-3-n-butyl-5-phenyl-4-(p-tolylsulfinyl)pent-4-enal

C₁₅H₁₈O