{(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

Base Information

Chemical Name:{(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester
CAS No.:930280-44-7
Molecular Formula:C₁₈H₂₈N₂O₃
Molecular Weight:320.432
Hs Code.:

Synonyms:{(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

Suppliers and Price of {(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl((S)-4-Methyl-2-[2-oxo-2-[[(S)-1-phenylethyl]amino]ethyl]pentyl]carbamate
5mg
$ 80.00

Total 6 raw suppliers

Chemical Property of {(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

Chemical Property:

Boiling Point:510.6±43.0 °C(Predicted)
Density:1.043±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

Methyl((S)-4-Methyl-2-[2-oxo-2-[[(S)-1-phenylethyl]amino]ethyl]pentyl]carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Methyl ((S)-4-Methyl-2-[2-oxo-2-[[(S)-1-phenylethyl]amino]ethyl]pentyl]carbamate is used in the synthetic preparation of (S)-Pregabalin (P704790), S-enantiomer of Pregabalin which is anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia.

Technology Process of {(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

There total 5 articles about {(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 67-56-1
methanol

: 930280-43-6
(R)-3-isobutylpentanedioic acid amide-((S)-1-phenylethyl)amide

: 930280-44-7
{(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

Guidance literature:: With bromine; sodium methylate; at -25 - 65 ℃; for 2 - 4h; Product distribution / selectivity;

Reference yield: 89.7%

: 67-56-1
methanol

: 930280-42-5
(3S)-5-methyl-3-(2-oxo-2-{[(1S)-1-phenylethyl]amino}ethyl)hexanoic acid

: 930280-44-7
{(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

Guidance literature:: (3S)-5-methyl-3-(2-oxo-2-{[(1S)-1-phenylethyl]amino}ethyl)hexanoic acid; With chloroformic acid ethyl ester; triethylamine; In acetone; at -20 - -10 ℃; for 1h;

With sodium azide; In water; acetone; at -20 - -10 ℃; for 1h;

methanol; In toluene; Reflux;

Reference yield:

: 185815-59-2
3-isobutylglutaric anhydride

: 930280-44-7
{(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / toluene / -15 - -10 °C

2.1: chloroformic acid ethyl ester; triethylamine / acetone / 1 h / -20 - -10 °C

2.2: 1 h / -20 - -10 °C

2.3: Reflux

With dmap; chloroformic acid ethyl ester; triethylamine; In acetone; toluene;