hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Base Information

Chemical Name:hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate
CAS No.:32719-58-7
Molecular Formula:C₅₇H₉₁N₅O₁₈
Molecular Weight:1134.37
Hs Code.:

hexa-tert-butyl N-<N-<N-<N-<N-(benzyloxycarbonyl)-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Synonyms:hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

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Chemical Property of hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

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Technology Process of hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

There total 12 articles about hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 88443-03-2
L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-glutamic acid pentakis-t-butyl ester

: 32719-58-7
hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 10 - 20 ℃; for 0.5h; Large scale;

L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-glutamic acid pentakis-t-butyl ester; In dichloromethane; at 20 ℃; for 20h; Large scale;

Reference yield:

: 88063-78-9
L-γ-glutamyl-L-glutamic acid tris-t-butyl ester

: 32719-58-7
hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

2: H₂ / 10percent Pd/C / methanol

3: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

4: H₂ / 10percent Pd/C / methanol

5: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00121a029

Reference yield:

: 32719-56-5
tri-tert-butyl N--L-glutamate

: 32719-58-7
hexa-tert-butyl N--L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10percent Pd/C / methanol

2: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

3: H₂ / 10percent Pd/C / methanol

4: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

5: H₂ / 10percent Pd/C / methanol

6: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00121a029