2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol

Base Information

Chemical Name:2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol
CAS No.:1189555-66-5
Molecular Formula:C₂₃H₃₁NO₂
Molecular Weight:353.505
Hs Code.:

Synonyms:2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol

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Chemical Property of 2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol

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Technology Process of 2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol

There total 10 articles about 2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189555-67-6
1-(4-Dimethylamino-4-phenylcyclohexyl)-2-phenoxyethanone

: 75-16-1
methylmagnesium bromide

: 1189555-66-5
2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol

Guidance literature:: 1-(4-Dimethylamino-4-phenylcyclohexyl)-2-phenoxyethanone; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h; Cooling with ice; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; Cooling with ice;

Reference yield:

: 93245-98-8
1,4-dioxaspiro[4.5]decane-8-carbaldehyde

: 1189555-66-5
2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.75 h / 20 °C

1.2: 18 h / 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide; water; mineral oil / 0.25 h / 20 °C

2.2: 5.5 h / 120 °C

3.1: hydrogenchloride; water / acetone / 48 h / 20 °C

4.1: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

5.1: hydrogenchloride / water; tetrahydrofuran; methanol / 6 h / 20 °C / Cooling with ice

6.1: tetrahydrofuran / 20 °C / Cooling with ice

7.1: hydrogenchloride; water / acetone / 20 °C

8.1: Dess-Martin periodane / dichloromethane / 5.5 h / 20 - 40 °C

9.1: diethyl ether; tetrahydrofuran / 3 h / 20 °C / Cooling with ice; Inert atmosphere

9.2: Cooling with ice

With hydrogenchloride; water; pyridinium p-toluenesulfonate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 108-95-2,27073-41-2
phenol

: 1189555-66-5
2-(4-dimethylamino-4-phenylcyclohexyl)-1-phenoxy-propan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; water; mineral oil / 0.25 h / 20 °C

1.2: 5.5 h / 120 °C

2.1: hydrogenchloride; water / acetone / 48 h / 20 °C

3.1: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

4.1: hydrogenchloride / water; tetrahydrofuran; methanol / 6 h / 20 °C / Cooling with ice

5.1: tetrahydrofuran / 20 °C / Cooling with ice

6.1: hydrogenchloride; water / acetone / 20 °C

7.1: Dess-Martin periodane / dichloromethane / 5.5 h / 20 - 40 °C

8.1: diethyl ether; tetrahydrofuran / 3 h / 20 °C / Cooling with ice; Inert atmosphere

8.2: Cooling with ice

With hydrogenchloride; water; pyridinium p-toluenesulfonate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;