(3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

Base Information

Chemical Name:(3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester
CAS No.:117828-41-8
Molecular Formula:C₂₈H₂₆O₇S
Molecular Weight:506.576
Hs Code.:

(3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

Synonyms:(3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

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Chemical Property of (3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

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Technology Process of (3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

There total 3 articles about (3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117828-39-4
(3aS,8bS)-2-(Bis-methylsulfanyl-methylene)-8b-hydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-2,3,3a,8b-tetrahydro-benzo[b]cyclopenta[d]furan-1-one

: 117828-41-8
(3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / acetonitrile; H₂O / 48 h / Heating

2: 1.) CuBr-Me₂S / 1.) diethyl ether, 0 deg C, 25 min, 2a.) -78 deg C, 1 h, 2b.) from -78 deg C to RT, 3 h

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In water; acetonitrile;
DOI:10.1021/jo00262a022

Reference yield:

: 117828-38-3
(3aS,8bS)-2-(Bis-methylsulfanyl-methylene)-6,8-dimethoxy-3a-(4-methoxy-phenyl)-8b-trimethylsilanyloxy-2,3,3a,8b-tetrahydro-benzo[b]cyclopenta[d]furan-1-one

: 117828-41-8
(3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / tetra-n-butylammonium fluoride

2: 56 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / acetonitrile; H₂O / 48 h / Heating

3: 1.) CuBr-Me₂S / 1.) diethyl ether, 0 deg C, 25 min, 2a.) -78 deg C, 1 h, 2b.) from -78 deg C to RT, 3 h

With tetrabutyl ammonium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In water; acetonitrile;
DOI:10.1021/jo00262a022

Reference yield:

: 117828-40-7
(3aS,8bS)-8b-Hydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-1-oxo-3a,8b-dihydro-1H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

: phenylmagnesium bromide

: 117828-41-8
(3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-3a,8b-dihydro-3H-benzo[b]cyclopenta[d]furan-2-carbothioic acid S-methyl ester

Guidance literature:: With 1.) CuBr-Me₂S; Yield given. Multistep reaction; 1.) diethyl ether, 0 deg C, 25 min, 2a.) -78 deg C, 1 h, 2b.) from -78 deg C to RT, 3 h;
DOI:10.1021/jo00262a022