Technology Process of (3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-2-carboxylic acid dimethylamide
There total 79 articles about (3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxy-phenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-2-carboxylic acid dimethylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; acetic acid;
In
acetonitrile;
at 20 ℃;
for 20h;
DOI:10.1002/anie.201501374
- Guidance literature:
-
N,N-dimethylammonium chloride; endo rocaglic acid;
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.583333h;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 13h;
With
hydrogenchloride;
In
water; N,N-dimethyl-formamide;
- Guidance literature:
-
With
1,1'-carbonyldiimidazole;
In
dichloromethane;
at 0 ℃;
for 6h;
DOI:10.1021/np970163+
![(2R,3S,3aR,8bR)-8b-hydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1-oxo-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide](/Databaselist/images/loading.webp)
