cis-4-methoxycyclohexane-1-carboxylic acid

Base Information

• Chemical Name: cis-4-methoxycyclohexane-1-carboxylic acid
• CAS No.: 73873-59-3
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.197
• Mol file: 73873-59-3.mol

Synonyms:4-methoxycyclohexanecarboxylic acid

Chemical Property of cis-4-methoxycyclohexane-1-carboxylic acid

Chemical Property:

• Melting Point: 54.8-55.8 °C
• Boiling Point: 266.6±33.0 °C(Predicted)
• PKA: 4.81±0.25(Predicted)
• Density: 1.09±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(1S,4s)-4-methoxycyclohexanecarboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: cis-4-Methoxycyclohexane-1-carboxylic Acid is used in the preparation of tricyclic guanidine derivs. useful as inhibitors of PDE1 in the treatment of neurological or psychiatric disorders.

Technology Process of cis-4-methoxycyclohexane-1-carboxylic acid

There total 2 articles about cis-4-methoxycyclohexane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxybenzoic acid (100-09-4) → 4-methoxycyclohexanecarboxylic acid (73873-59-3) + trans-4-methoxycyclohexane-1-carboxylic acid (73873-61-7)

Guidance literature:

With hydrogen; In 1,4-dioxane; at 20 ℃; under 760.051 Torr; Overall yield = 27 percent; Optical yield = 72 percent de; chemoselective reaction;

DOI:10.1039/d1ob01197a

Reference yield:

Methyl cis/trans-4-methoxycyclohexanecarboxylate (137058-17-4) → 4-methoxycyclohexanecarboxylic acid (73873-59-3) + trans-4-methoxycyclohexane-1-carboxylic acid (73873-61-7)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01569a030

Reference yield:

4-methoxycyclohexanecarboxylic acid (73873-59-3) → methyl cyclohex-3-ene-1-carboxylate (6493-77-2) + trans-4-chloro-cyclohexanecarboxylic acid methyl ester (26041-76-9)

Guidance literature:

With thionyl chloride;

DOI:10.1021/ja01569a030 DOI:10.1021/ja01053a033

upstream raw materials:

Methyl cis/trans-4-methoxycyclohexanecarboxylate

4-methoxybenzoic acid

Downstream raw materials:

methyl cyclohex-3-ene-1-carboxylate

trans-4-chloro-cyclohexanecarboxylic acid methyl ester

trans-4-bromo-cyclohexanecarboxylic acid methyl ester

3-(4-methoxy-cyclohexyl)-3-oxo-propionic acid ethyl ester