7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1258457-95-2
Molecular Formula:C₂₃H₂₀F₃N₃O₃
Molecular Weight:443.425
Hs Code.:

Synonyms:7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid

There total 4 articles about 7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1258458-32-0
7-fluoro-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 1258457-95-2
7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 105 ℃; for 4h;
DOI:10.1002/cmdc.201000267

Reference yield:

: 1185019-02-6
C₁₄H₁₅ClFNO₃

: 1258457-95-2
7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; ethanol / 12 h / 20 °C

2: caesium carbonate / acetonitrile / 3 h / Reflux

3: sodium hydroxide / water / 1 h / pH 5 / Reflux

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 105 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In diethyl ether; ethanol; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/cmdc.201000267

Reference yield:

: 1258458-27-3
ethyl 3-[(2-chloroethyl)amino]-2-(2-chloro-4-fluorobenzoyl)prop-2-enoate

: 1258457-95-2
7-{4-[3-trifluoromethylphenyl]piperazin-1-yl}-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 3 h / Reflux

2: sodium hydroxide / water / 1 h / pH 5 / Reflux

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 105 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/cmdc.201000267