(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate

Base Information

Chemical Name:(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate
CAS No.:1311271-13-2
Molecular Formula:C₁₉H₁₈BrNO₅
Molecular Weight:420.26
Hs Code.:

Synonyms:(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate

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Chemical Property of (5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate

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Technology Process of (5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate

There total 3 articles about (5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 5-bromo-4-methoxy-2-methoxymethoxybenzaldehyde

: 623-00-7
4-bromobenzenecarbonitrile

: 75-36-5
acetyl chloride

: 1311271-13-2
(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate

Guidance literature:: 4-bromobenzenecarbonitrile; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

5-bromo-4-methoxy-2-methoxymethoxybenzaldehyde; In tetrahydrofuran; pentane; at -78 - 20 ℃; for 2.16667h;

acetyl chloride; In tetrahydrofuran; pentane; at 20 ℃; for 2h; Cooling with ice;
DOI:10.1016/j.tet.2011.03.059

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 1311271-13-2
(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; acetic acid / 1 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C

3.2: 2.17 h / -78 - 20 °C

3.3: 2 h / 20 °C / Cooling with ice

With bromine; tert.-butyl lithium; sodium hydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1016/j.tet.2011.03.059

Reference yield:

: 57543-36-9
5-bromo-2-hydroxy-4-methoxybenzaldehyde

: 1311271-13-2
(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)(4-cyanophenyl)methyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 2.17 h / -78 - 20 °C

2.3: 2 h / 20 °C / Cooling with ice

With tert.-butyl lithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1016/j.tet.2011.03.059