2-(Methylsulfonyl)ethyl carbonochloridate

Base Information

• Chemical Name: 2-(Methylsulfonyl)ethyl carbonochloridate
• CAS No.: 53298-29-6
• Molecular Formula: C4H7 Cl O4 S
• Molecular Weight: 186.616
• Hs Code.: 2915900090
• European Community (EC) Number: 258-463-1
• UNII: S37868WS9L
• DSSTox Substance ID: DTXSID80201437
• Nikkaji Number: J40.689I
• Wikidata: Q83074662
• Mol file: 53298-29-6.mol

Synonyms:methylsulfonylethyloxycarbonyl group

Chemical Property of 2-(Methylsulfonyl)ethyl carbonochloridate

Chemical Property:

• Vapor Pressure: 0.000118mmHg at 25°C
• Boiling Point: 335.6°Cat760mmHg
• Flash Point: 156.8°C
• PSA: 68.82000
• Density: 1.43g/cm³
• LogP: 1.48720
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 185.9753576
• Heavy Atom Count: 10
• Complexity: 202

Purity/Quality:

99% ^*data from raw suppliers

2-(Methylsulfonyl)ethylcarbonochloridate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)CCOC(=O)Cl

Technology Process of 2-(Methylsulfonyl)ethyl carbonochloridate

There total 2 articles about 2-(Methylsulfonyl)ethyl carbonochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) + 2-(methylsulfonyl)ethyl alcohol (15205-66-0) → 2-methylsulfonyl ethyloxycarbonyl chloride (53298-29-6)

Guidance literature:

DOI:10.1021/jo00937a018

Reference yield:

→ 2-methylsulfonyl ethyloxycarbonyl chloride (53298-29-6)

Guidance literature:

β-Methylsulfonylethanol, COCl2/THF;

Reference yield: 98.0%

ethyl 2,3,4-tri-O-benzyl-1-thio-β-D-glucopyranoside (39483-51-7,119645-03-3,128850-50-0,126461-54-9) + 2-methylsulfonyl ethyloxycarbonyl chloride (53298-29-6) → ethyl 2,3,4-tri-O-benzyl-6-O-methylsulfonylethoxycarbonyl-1-thio-β-D-glucopyranoside (1154463-04-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2009.02.146

upstream raw materials:

phosgene

2-(methylsulfonyl)ethyl alcohol

Downstream raw materials:

1-Methyl-2-[N-[4-[N-[2-(methylsulphonyl)ethyloxycarbonyl]-amidino]phenyl]-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide

1-Methyl-2-[N-[4-[N-(2-methylsulphonyl-ethyloxycarbonyl)amidino]-phenyl]-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide

1-Methyl-2-[N-[4-[N-(2-methylsulphonyl-ethyloxycarbonyl)amidino]-phenyl]-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-ethoxycarbonylmethyl-amide

methyl 2,3-di-O-benzyl-6-O-dimethoxytrityl-4-O-methylsulfonylethoxycarbonyl-α-D-glucopyranoside

Refernces

• 1、 Wolters,Tesser,Nivard. "Synthesis of the A 14-21 sequence of ovine insulin by the solid-phase technique.". . p. 3388 - 3392. Retrieved 2007/10/08.