(S)-2-(benzylamino)-3-((tert-butyldimethylsilyl)oxy)propan-1-ol

Base Information

Chemical Name:(S)-2-(benzylamino)-3-((tert-butyldimethylsilyl)oxy)propan-1-ol
CAS No.:794518-59-5
Molecular Formula:C₁₆H₂₉NO₂Si
Molecular Weight:295.497
Hs Code.:
Mol file:794518-59-5.mol

Synonyms:(2S)-2-(benzylamino)-3-{[tert-butyl(dimethyl)silyl]oxy}-1-propanol

Suppliers and Price of (S)-2-(benzylamino)-3-((tert-butyldimethylsilyl)oxy)propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (S)-2-(benzylamino)-3-((tert-butyldimethylsilyl)oxy)propan-1-ol

Chemical Property:

Boiling Point:375.2±37.0 °C(Predicted)
PKA:14.34±0.10(Predicted)
Density:0.974±0.06 g/cm3(Predicted)

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-(benzylamino)-3-((tert-butyldimethylsilyl)oxy)propan-1-ol

There total 3 articles about (S)-2-(benzylamino)-3-((tert-butyldimethylsilyl)oxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123639-56-5,131110-76-4,144001-42-3
methyl (2R)-2-(benzylamino)-3-hydroxypropanoate

: 794518-59-5
(2S)-2-(benzylamino)-3-{[tert-butyl(dimethyl)silyl]oxy}-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N; DMAP / CH₂Cl₂ / 12 h / 20 °C

2: 47 percent / LiBH₄ / tetrahydrofuran; toluene / 0.33 h / 100 °C

With dmap; lithium borohydride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/ejoc.200400824

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 794518-59-5
(2S)-2-(benzylamino)-3-{[tert-butyl(dimethyl)silyl]oxy}-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: lithium borohydride; methanol / tetrahydrofuran / 16 h / 20 °C

With methanol; dmap; lithium borohydride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 100-52-7
benzaldehyde

: 794518-59-5
(2S)-2-(benzylamino)-3-{[tert-butyl(dimethyl)silyl]oxy}-1-propanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 0.17 h / 0 °C

1.2: 2 h

1.3: 5.5 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 16 h / 0 - 20 °C

3.1: lithium borohydride; methanol / tetrahydrofuran / 16 h / 20 °C

With methanol; dmap; lithium borohydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;