(2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

Base Information

Chemical Name:(2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine
CAS No.:918160-17-5
Molecular Formula:C₃₃H₄₀N₂O₅Si
Molecular Weight:572.777
Hs Code.:

Synonyms:(2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

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Chemical Property of (2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

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Technology Process of (2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

There total 3 articles about (2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50424-51-6,182823-26-3
(2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

: 918160-17-5
(2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / imidazole / dimethylformamide / 12 h / 20 °C

2: 89 percent / NaH / tetrahydrofuran; various solvent(s) / 0 °C

With 1H-imidazole; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0640142

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 918160-17-5
(2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / imidazole / dimethylformamide / 12 h / 20 °C

2: 89 percent / NaH / tetrahydrofuran; various solvent(s) / 0 °C

With 1H-imidazole; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0640142

Reference yield:

: 728-87-0
4,4'-Dimethoxybenzhydrol

: 918160-17-5
(2R,11aS)-(-)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / acetyl bromide / benzene / 1 h / 20 °C

2: 89 percent / NaH / tetrahydrofuran; various solvent(s) / 0 °C

With Acetyl bromide; sodium hydride; In tetrahydrofuran; benzene;
DOI:10.1021/ja0640142