4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane

Base Information

• Chemical Name: 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane
• CAS No.: 1276543-57-7
• Molecular Formula: C₃₀H₄₉N₅O₆
• Molecular Weight: 575.749
• Mol file: 1276543-57-7.mol

Synonyms:4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane

Chemical Property of 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane

There total 7 articles about 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate) (134439-25-1) + (7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester (162148-48-3) → 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane (1276543-57-7)

Guidance literature:

With sodium carbonate; In toluene; for 144h; Reflux;

Reference yield:

1,4,7,10-tetraazacyclododecan (294-90-6) → 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane (1276543-57-7)

Guidance literature:

Multi-step reaction with 5 steps

1: chloroform / 10 h / 0 - 20 °C

2: sodium hydroxide / water

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 10 h / 60 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

5: sodium carbonate / toluene / 144 h / Reflux

With hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In ethanol; chloroform; water; toluene; acetonitrile;

Reference yield:

dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate (187240-78-4) → 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane (1276543-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

2: sodium carbonate / toluene / 144 h / Reflux

With hydrogen; sodium carbonate; palladium 10% on activated carbon; In ethanol; toluene;

upstream raw materials:

diethyl 2-(4-nitrobenzyl)malonate

1,4,7,10-tetraazacyclododecan

2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate)

(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

Downstream raw materials:

4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane