4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane

Base Information

• Chemical Name: 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane
• CAS No.: 1276543-58-8
• Molecular Formula: C₃₀H₅₁N₅O₄
• Molecular Weight: 545.766
• Mol file: 1276543-58-8.mol

Synonyms:4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane

Chemical Property of 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane

There total 10 articles about 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane (1276543-57-7) → 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane (1276543-58-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 12h;

Reference yield:

diethyl 2-(4-nitrobenzyl)malonate (7598-70-1) → 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane (1276543-58-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol / 16 h / Reflux

2: pyridine / 10 h / 0 - 20 °C

3: sodium carbonate / toluene / 144 h / Reflux

4: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

With pyridine; sodium tetrahydroborate; hydrogen; sodium carbonate; palladium 10% on activated carbon; In ethanol; toluene;

Reference yield:

1,4,7,10-tetraazacyclododecan (294-90-6) → 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane (1276543-58-8)

Guidance literature:

Multi-step reaction with 6 steps

1: chloroform / 10 h / 0 - 20 °C

2: sodium hydroxide / water

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 10 h / 60 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

5: sodium carbonate / toluene / 144 h / Reflux

6: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C

With hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In ethanol; chloroform; water; toluene; acetonitrile;

upstream raw materials:

diethyl 2-(4-nitrobenzyl)malonate

1,4,7,10-tetraazacyclododecan

2-[(4-nitrophenyl)methyl]propan-1,3-diol

dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

Downstream raw materials:

4,10-bis-(carboxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[5.5.3]pentadecane