N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide

Base Information

• Chemical Name: N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide
• CAS No.: 1198335-22-6
• Molecular Formula: C₂₂H₃₀N₂O₃S
• Molecular Weight: 402.558
• Mol file: 1198335-22-6.mol

Synonyms:N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide

Chemical Property of N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide

There total 3 articles about N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Chloro-N,N-diethylacetamide (2315-36-8) + N-(3-phenylpropylidene)-S-(4-methylphenyl)sulfonamide (175355-35-8) → N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide (1198335-22-6)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 20 ℃; for 3.5h;

DOI:10.1002/adsc.200900189 DOI:10.1002/adsc.200900534

Reference yield: 57.0%

(2-(diethylamino)-2-oxoethyl)zinc chloride + N-(3-phenylpropylidene)-S-(4-methylphenyl)sulfonamide (175355-35-8) → N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide (1198335-22-6)

Guidance literature:

In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;

DOI:10.1002/bkcs.11019

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + toluene-4-sulfonamide (70-55-3) → N,N-diethyl-3-(4-methylphenylsulfonamido)-5-phenylpentanamide (1198335-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium 4-methylbenzenesulfinate / 20 °C

2: tetrahydrofuran / 1 h / Inert atmosphere; Reflux

With sodium 4-methylbenzenesulfinate; In tetrahydrofuran;

DOI:10.1002/bkcs.11019

upstream raw materials:

2-Chloro-N,N-diethylacetamide

N-(3-phenylpropylidene)-S-(4-methylphenyl)sulfonamide

3-phenyl-propionaldehyde

toluene-4-sulfonamide