tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate
CAS No.:1315326-91-0
Molecular Formula:C₄₃H₅₃N₇O₁₀S
Molecular Weight:860.001
Hs Code.:

tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Synonyms:tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

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Chemical Property of tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

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Technology Process of tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

There total 8 articles about tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 1315326-90-9
(2S,4R)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridin[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

: 1315326-91-0
tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; HATU; In dichloromethane; at 20 ℃;

Reference yield:

: 1315326-84-1
2-[(2-cyanopyridin-3-yl)oxy]acetamide

: 1315326-91-0
tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 80 °C

2.1: pyridine / tetrahydrofuran / 18 h / 0 - 60 °C

3.1: potassium tert-butylate / water; tert-butyl alcohol / 23 h / 75 °C

3.2: pH 2

4.1: trichlorophosphate / 1,4-dioxane / 2.5 h / 0 - 110 °C

4.2: pH 8

5.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 20 °C

5.2: 2 h / 20 °C

5.3: pH 3

6.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 2 h / 20 °C

7.1: thionyl chloride / methanol / 4 h / 45 °C

8.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

With 4-methyl-morpholine; pyridine; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 917504-84-8
3-aminofuro[3,2-b]pyridine-2-carboxamide

: 1315326-91-0
tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / tetrahydrofuran / 18 h / 0 - 60 °C

2.1: potassium tert-butylate / water; tert-butyl alcohol / 23 h / 75 °C

2.2: pH 2

3.1: trichlorophosphate / 1,4-dioxane / 2.5 h / 0 - 110 °C

3.2: pH 8

4.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 20 °C

4.2: 2 h / 20 °C

4.3: pH 3

5.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 2 h / 20 °C

6.1: thionyl chloride / methanol / 4 h / 45 °C

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

With 4-methyl-morpholine; pyridine; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;