(2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

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Chemical Name:(2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide
CAS No.:1315326-93-2
Molecular Formula:C₃₉H₄₆N₈O₈S₂
Molecular Weight:818.975
Hs Code.:

(2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

Synonyms:(2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

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Chemical Property of (2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

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Technology Process of (2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

There total 11 articles about (2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315326-92-1
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 1315326-93-2
(2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

Guidance literature:: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt; 1,1'-Thiocarbonyldiimidazole; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With ammonia; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 3h;

Reference yield:

: 932-35-4
3-hydroxypyridine-2-carbonitrile

: 1315326-93-2
(2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

2.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 80 °C

3.1: pyridine / tetrahydrofuran / 18 h / 0 - 60 °C

4.1: potassium tert-butylate / water; tert-butyl alcohol / 23 h / 75 °C

4.2: pH 2

5.1: trichlorophosphate / 1,4-dioxane / 2.5 h / 0 - 110 °C

5.2: pH 8

6.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 20 °C

6.2: 2 h / 20 °C

6.3: pH 3

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 2 h / 20 °C

8.1: thionyl chloride / methanol / 4 h / 45 °C

9.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

10.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C

11.1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

11.2: 3 h / 0 - 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; triethylamine; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1315326-84-1
2-[(2-cyanopyridin-3-yl)oxy]acetamide

: 1315326-93-2
(2S,4R)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinyl-cyclopropyl)-1-((S)-3,3-dimethyl-2-thioureidobutanoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 80 °C

2.1: pyridine / tetrahydrofuran / 18 h / 0 - 60 °C

3.1: potassium tert-butylate / water; tert-butyl alcohol / 23 h / 75 °C

3.2: pH 2

4.1: trichlorophosphate / 1,4-dioxane / 2.5 h / 0 - 110 °C

4.2: pH 8

5.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 20 °C

5.2: 2 h / 20 °C

5.3: pH 3

6.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 2 h / 20 °C

7.1: thionyl chloride / methanol / 4 h / 45 °C

8.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

9.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C

10.1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

10.2: 3 h / 0 - 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; triethylamine; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;