(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

Base Information

Chemical Name:(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt
CAS No.:1315326-92-1
Molecular Formula:C₃₈H₄₅N₇O₈S*ClH
Molecular Weight:796.344
Hs Code.:

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

Synonyms:(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

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Chemical Property of (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

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Technology Process of (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

There total 10 articles about (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315326-91-0
tert-butyl (2S)-1-((2S,4R)-2-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropylcarbamoyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

: 1315326-92-1
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 ℃;

Reference yield:

: 932-35-4
3-hydroxypyridine-2-carbonitrile

: 1315326-92-1
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

2.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 80 °C

3.1: pyridine / tetrahydrofuran / 18 h / 0 - 60 °C

4.1: potassium tert-butylate / water; tert-butyl alcohol / 23 h / 75 °C

4.2: pH 2

5.1: trichlorophosphate / 1,4-dioxane / 2.5 h / 0 - 110 °C

5.2: pH 8

6.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 20 °C

6.2: 2 h / 20 °C

6.3: pH 3

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 2 h / 20 °C

8.1: thionyl chloride / methanol / 4 h / 45 °C

9.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

10.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1315326-84-1
2-[(2-cyanopyridin-3-yl)oxy]acetamide

: 1315326-92-1
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxyphenyl)furo[3,2-b]pyridine[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 80 °C

2.1: pyridine / tetrahydrofuran / 18 h / 0 - 60 °C

3.1: potassium tert-butylate / water; tert-butyl alcohol / 23 h / 75 °C

3.2: pH 2

4.1: trichlorophosphate / 1,4-dioxane / 2.5 h / 0 - 110 °C

4.2: pH 8

5.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 20 °C

5.2: 2 h / 20 °C

5.3: pH 3

6.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 2 h / 20 °C

7.1: thionyl chloride / methanol / 4 h / 45 °C

8.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

9.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;