methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

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Chemical Name:methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate
CAS No.:1186390-24-8
Molecular Formula:C₂₇H₂₁FN₆O₃
Molecular Weight:496.501
Hs Code.:

Synonyms:methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

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Chemical Property of methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

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Technology Process of methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

There total 6 articles about methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1186390-14-6
2-(3-(7-bromoquinazolin-4-ylamino)-1H-pyrazol-5-yl)-N-(3-fluorophenyl)acetamide

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1186390-24-8
methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

Guidance literature:: With 18-crown-6 ether; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 90 ℃;

Reference yield:

: 174891-10-2
(5-amino-2H-pyrazol-3-yl)acetic acid

: 1186390-24-8
methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 2.5 h / 100 - 102 °C

2: 2-hydroxy-pyridine N-oxide; 3-methyl-N-(3-methylbutyl)-1-butanamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3: 18-crown-6 ether; cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C

With 2-hydroxy-pyridine N-oxide; 18-crown-6 ether; 3-methyl-N-(3-methylbutyl)-1-butanamine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 573675-55-5
7-bromo-4-chloro-quinazoline

: 1186390-24-8
methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 2.5 h / 100 - 102 °C

2: 2-hydroxy-pyridine N-oxide; 3-methyl-N-(3-methylbutyl)-1-butanamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3: 18-crown-6 ether; cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C

With 2-hydroxy-pyridine N-oxide; 18-crown-6 ether; 3-methyl-N-(3-methylbutyl)-1-butanamine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;