C₁₉H₂₆N₂O₆S

Base Information

• Chemical Name: C₁₉H₂₆N₂O₆S
• CAS No.: 1288978-76-6
• Molecular Formula: C₁₉H₂₆N₂O₆S
• Molecular Weight: 410.491
• Mol file: 1288978-76-6.mol

Synonyms:C₁₉H₂₆N₂O₆S

Chemical Property of C₁₉H₂₆N₂O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₆N₂O₆S

There total 7 articles about C₁₉H₂₆N₂O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

isocyanate de chlorosulfonyle (1189-71-5) + C16H23NO2 (1313617-09-2) + 2-chloro-ethanol (107-07-3) → C19H26N2O6S (1288978-76-6)

Guidance literature:

With 4-methyl-morpholine; In acetonitrile; at 50 ℃; for 2h;

DOI:10.1021/jm101609j

Reference yield:

(2RS,3RS)-dimethyl 2,3-dimethyl-2-phenylcyclopropane-1,1-dicarboxylate → C19H26N2O6S (1288978-76-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 12 h / 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / 12 h / 100 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 12 h / 90 °C

4.1: potassium hydrogensulfate / ethyl acetate

4.2: 2 h / 100 °C

5.1: toluene-4-sulfonic acid / methanol / 12 h / 20 °C

6.1: 4-methyl-morpholine / acetonitrile / 2 h / 50 °C

With 4-methyl-morpholine; potassium hydrogensulfate; diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate; acetonitrile; 2.1: Curtius rearrangement;

DOI:10.1021/jm101609j

Reference yield:

(1S,2R,3R)-1-tert-butoxycarbonylamino-2,3-dimethyl-2-phenylcyclopropane-1-carboxylic acid quinidine (1315594-67-2) → C19H26N2O6S (1288978-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydrogensulfate / ethyl acetate

1.2: 2 h / 100 °C

2.1: toluene-4-sulfonic acid / methanol / 12 h / 20 °C

3.1: 4-methyl-morpholine / acetonitrile / 2 h / 50 °C

With 4-methyl-morpholine; potassium hydrogensulfate; toluene-4-sulfonic acid; In methanol; ethyl acetate; acetonitrile;

DOI:10.1021/jm101609j

upstream raw materials:

isocyanate de chlorosulfonyle

C₁₆H₂₃NO₂

2-chloro-ethanol

(1S,2R,3R)-1-tert-butoxycarbonylamino-2,3-dimethyl-2-phenylcyclopropane-1-carboxylic acid quinidine

Downstream raw materials:

(1S,2R,3R)-2,3-dimethyl-1-(7-fluoro-1,2,3,4-tetrahydropyrido[3',4':3,4]pyrazolo[1,5-a]pyridine-2-sulfonylamino)-2-phenylcyclopropane-1-carboxylic acid

(1S,2R,3R)-2,3-dimethyl-1-(8-fluoro-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-2-sulfonylamino)-2-phenylcyclopropane-1-carboxylic acid

(1S,2R,3R)-1-[(R)-4-(5-cyanothiophen-2-yl)-3-methylpiperazine-1-sulfonylamino]-2,3-dimethyl-2-phenylcyclopropane-1-carboxylic acid

(1S,2R,3R)-1-[(R)-4-(5-difluoromethylisoxazol-3-yl)-3-methylpiperazine-1-sulfonylamino]-2,3-dimethyl-2-phenylcyclopropane-1-carboxylic acid