1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea

Base Information

Chemical Name:1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea
CAS No.:162757-17-7
Molecular Formula:C₂₁H₂₅N₇O₅S₂
Molecular Weight:519.605
Hs Code.:

Synonyms:1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea

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Chemical Property of 1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea

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Technology Process of 1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea

There total 8 articles about 1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 21950-36-7
5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine

: 13068-20-7
N-bis-(methylsulfanylmethylene)benzenesulfonamide

: 162757-17-7
1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea

Guidance literature:: In pyridine; at 80 ℃; for 4h;
DOI:10.1080/15257779508014657

Reference yield:

: 68179-90-8,7687-45-8
((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl methanesulfonate

: 162757-17-7
1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea

Guidance literature:: Multi-step reaction with 6 steps

1: Ambient temperature

2: 88 percent / NH₃/EtOH / 1.5 h

3: 84 percent / NaN₃ / dimethylformamide / 45 h / 80 °C

4: 66 percent / NH₃, MeOH / 40 h / Ambient temperature

5: 70 percent / H₂ / Pd-C / ethanol / 5 h / 2327.2 Torr

6: 93 percent / pyridine / 4 h / 80 °C

With methanol; sodium azide; ethanol; ammonia; hydrogen; palladium on activated charcoal; In pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1080/15257779508014657

Reference yield:

: 40653-96-1
N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-methylsulfonyladenosine

: 162757-17-7
1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / NaN₃ / dimethylformamide / 45 h / 80 °C

2: 66 percent / NH₃, MeOH / 40 h / Ambient temperature

3: 70 percent / H₂ / Pd-C / ethanol / 5 h / 2327.2 Torr

4: 93 percent / pyridine / 4 h / 80 °C

With methanol; sodium azide; ammonia; hydrogen; palladium on activated charcoal; In pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1080/15257779508014657