13068-20-7Relevant academic research and scientific papers
Discovery, synthesis,andevaluation of small-molecule signal transducer and activator of transcription 3 inhibitors
Shi, Zhi-Bing,Zhao, Dan,Huang, Yan-Yan,Du, Yun,Cao, Xiang-Rong,Gong, Zhu-Nan,Zhao, Rui,Li, Jian-Xin
, p. 1574 - 1580 (2013/02/23)
The signal transducer and activator of transcription 3 (STAT3) oncogene is a promising molecular target and its inhibitors have great potential as anticancer drugs. To identify novel and STAT3-selective inhibitors, a virtual screening based on Specs and M
N′-(Arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT6R) antagonists with unique structural features
Van Loevezijn, Arnold,Venhorst, Jennifer,Iwema Bakker, Wouter I.,De Korte, Cor G.,De Looff, Wouter,Verhoog, Stefan,Van Wees, Jan-Willem,Van Hoeve, Martijn,Van De Woestijne, Rob P.,Van Der Neut, Martina A. W.,Borst, Alice J. M.,Van Dongen, Maria J. P.,De Bruin, Natasja M. W. J.,Keizer, Hiskias G.,Kruse, Chris G.
supporting information; experimental part, p. 7030 - 7054 (2011/12/15)
The 5-HT6 receptor (5-HT6R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT6R antagonists to improve off-target selectivity compared to basic amine-con
Synthesis of Pyrrazoles and Pyrazolopyrimidines from 3-Arylsulfonylaminoacrylates
McFadden, Helen G.,Huppatz, John L.,Halladay, Peter K.
, p. 873 - 886 (2007/10/02)
3-Arylsulfonylaminopyrazole-4-carboxamides and -carboxylates were synthesized from 3-arylsulfonylamino-3-methylthiocyanoacrylate derivatives as potential herbicidal inhibitors of the enzyme acetohydroxyacetic acid synthase (AHAS). Some of these compounds
Regiospecific synthesis of N-sulfonyl derivatives of 3,5-diamino-1H-1,2,4-triazole and 2,5-diamino-1,3,4-thiadiazole
Maybhate,Rajamohanan,Rajappa
, p. 220 - 222 (2007/10/02)
Condensation of the S,S-dimethyl N-(alkylsulfonyl)carbondithioimidates 1 with aminoguanidine bicarbonate and hydrazinecarbothioamide leads to the regiospecific synthesis of N-sulfonyl derivatives of 3,5-diamino-1H-1,2,4-triazole 2 and 2,5-diamino-1,3,4-thiadiazole 3, respectively.
