40653-96-1

Upstream product

• 40982-79-4 N⁶,N⁶-dibenzoyl-5'-O-mesyl-2',3'-O-isopropylidene adenosine 
• 124-63-0 methanesulfonyl chloride 
• 98-88-4 benzoyl chloride 
• 58-61-7 adenosine 
• 362-75-4 2',3'-isopropylidene adenosine 
• 68179-90-8 ((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl methanesulfonate 
• 77-76-9 2,2-dimethoxy-propane 
• 4546-55-8 N-benzoyladenosine 
• 39947-04-1 N-6-benzoyl-2',3'-O-isopropylideneadenosine 

Downstream Products

• 33962-29-7 N-(9-((3aR,4R,6aS)-2,2-dimethyl-6-methylenetetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)benzamide 
• 68144-26-3 5'-azido-5'-deoxy-N⁶-benzoyl-2',3'-O-isopropylidene adenosine 
• 949572-36-5 C₂₃H₂₄N₇O₆Cl 
• 57610-04-5 N⁶-benzoyl-5'-azidoadenosine 
• 14365-44-7 5'-amino-5'-deoxyadenosine 
• 737-76-8 5'-azido-5'-deoxyadenosine 
• 256643-14-8 5'-amino-5'-deoxy-2',3'-O-isopropylidene-N⁶-benzoyladenosine 
• 21950-36-7 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine 
• 34245-48-2 5'-azido-5'-deoxy-2',3'-O-isopropylidene adenosine 
• 162757-17-7 1-(5'-deoxy-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonylisothiourea 
• 162757-20-2 5'-amino-5'-deoxy-N⁶-benzoyl-3'-O,5'-N-(N-phenylsulfonyliminocarbonyl)adenosine 
• 162757-19-9 1-(N⁶-benzoyl-5'-deoxy-adenosin-5'-yl)-2-methyl-3-phenylsulfonyl-isothiourea 
• 162757-18-8 1-(5'-deoxy-N⁶,N⁶-dibenzoyl-2',3'-O-isopropylidene adenosin-5'-yl)-2-methyl-3-phenylsulfonyl-isothiourea 
• 59996-36-0 N⁶,N⁶-dibenzoyl-9-(5-deoxy-2,3-O-isopropylidene-β-D-erythropent-4-enofuranosyl)adenine 

Relevant academic research and scientific papers

Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase

5′-Deoxy-5′-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5′-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeli

Synthesis of an uncharged cAMP-analogue

3'-O,5'-N-(N-phenylsulfonyliminocarbonyl)-5'-amino-5'-deoxy adenosine, an uncharged cAMP-analogue was synthesized. This was accomplished by treatment of 5'amino-5'-deoxy-2',3'-O-isopropylidene adenosine with dimethyl N-phenylsulfonyldithiocarbamate. After removal of the isopropylidene protecting group and treatment of the intermediate with benzoyl chloride, cyclisation was carried out in DMF containing 10 equivalents of potassium tert-butoxide. Final deprotection of the adenine moiety was carried out with hydrazine hydrate.

Synthetic Approaches towards Nucleocidin and Selected Analogues; anti-HIV Activity in 4'-Fluorinated Nucleoside Derivatives

Nucleocidin 1 has been synthesised from the adenosine derivative 4 via the intermediacy of the dihalogeno compound 9.The latter compound showed slight but significant activity against HIV-infected cells while the isomer 10 and the monohalogeno compound 60 were inactive.Synthetic approaches towards other 4'-fluorinated nucleoside derivatives are also described.The epimeric 4'-fluorinated nucleosides 26 and 27 displayed similar activity against HIV-infected cells to that observed for the dihalogenated compound 9.