6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one

Base Information

Chemical Name:6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one
CAS No.:1361569-23-4
Molecular Formula:C₂₀H₁₇FN₈O
Molecular Weight:404.406
Hs Code.:

Synonyms:6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one

Suppliers and Price of 6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-7,9-dimethyl-7H-purin-8(9H)-one
50mg
$ 625.00

TRC
6-Amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-7,9-dimethyl-7H-purin-8(9H)-one
25mg
$ 420.00

TRC
6-Amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-7,9-dimethyl-7H-purin-8(9H)-one
5mg
$ 120.00

ChemScene
Guanylatecyclase-IN-1 ≥99.0%
100mg
$ 1720.00

Total 7 raw suppliers

Chemical Property of 6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one

Chemical Property:

Boiling Point:549.3±50.0 °C(Predicted)
Density:1.56±0.1 g/cm3(Predicted)

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-7,9-dimethyl-7H-purin-8(9H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of 6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one

There total 2 articles about 6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1361569-18-7
6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-methyl-7,9-dihydro-8H-purin-8-one

: 74-88-4
methyl iodide

: 1361569-23-4
6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

Reference yield:

: 625115-55-1
Riociguat

: 1361569-23-4
6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dimethyl-7,9-dihydro-8H-purin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 19 h / 0 - 20 °C

2: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / N,N-dimethyl-formamide / 3 h / 0 °C

With sodium hexamethyldisilazane; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In tetrahydrofuran; N,N-dimethyl-formamide;