4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide

Base Information

Chemical Name:4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide
CAS No.:1603899-71-3
Molecular Formula:C₂₉H₃₂F₂N₄O₂
Molecular Weight:506.595
Hs Code.:

Synonyms:4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide

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Chemical Property of 4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide

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Technology Process of 4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide

There total 4 articles about 4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1603897-67-1
4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-2-methylpyrimidine-5-carboxamide

: 74-88-4
methyl iodide

: 1603899-71-3
4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide

Guidance literature:: 4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-2-methylpyrimidine-5-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.0833333h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 1603907-36-3
4-(1-(2-(2, 6-difluorophenyl)acetyl)piperidin-4-yl)-2-methylpyrimidine-5-carboxylic acid

: 1603899-71-3
4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 20 °C

2.2: 2 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 85068-28-6
2,6-difluorophenylacetic acid

: 1603899-71-3
4-(1-(2-(2,6-difluorophenyl)acetyl)piperidin-4-yl)-N-(3,5-dimethylbenzyl)-N,2-dimethylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 5 h / 20 °C

2.1: methanol; sodium hydroxide; water / 10 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 20 °C

4.2: 2 h / 20 °C

With methanol; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;